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Diltiazem Hcl Injection Generic Name & Formulations
Legal Class
Rx
General Description
Diltiazem HCl 5mg/mL; soln for IV inj or infusion after dilution.
Pharmacological Class
Calcium channel blocker (CCB) (benzothiazepine).
How Supplied
Contact supplier.
Manufacturer
Diltiazem Hcl Injection Indications
Indications
Temporary control of rapid ventricular rate in atrial fibrillation or flutter. Rapid conversion of paroxysmal supraventricular tachycardias (PSVT) to sinus rhythm.
Diltiazem Hcl Injection Dosage and Administration
Adult
Direct IV single injections (bolus): initially 0.25mg/kg over 2 minutes; if needed, may give second dose (0.35mg/kg) after 15 minutes; subsequent bolus doses should be individualized. If continuous IV infusion is needed, begin immediately after bolus administration. Initial infusion rate: 10mg/h; may increase in 5mg/h increments up to 15mg/h. May be maintained for up to 24 hours.
Children
Not recommended.
Diltiazem Hcl Injection Contraindications
Contraindications
Sick sinus syndrome or 2nd- or 3rd-degree AV block (unless paced). Severe hypotension. Cardiogenic shock. Concomitant IV β-blockers. Atrial fibrillation or flutter associated with an accessory bypass tract such as in Wolff-Parkinson-White syndrome or short PR syndrome. Ventricular tachycardia.
Diltiazem Hcl Injection Boxed Warnings
Not Applicable
Diltiazem Hcl Injection Warnings/Precautions
Warnings/Precautions
Have resuscitative equipment readily available. CHF. Renal or hepatic impairment. Hemodynamically compromised. Continuously monitor ECG and blood pressure. Pregnancy (Cat.C). Nursing mothers: not recommended.
Diltiazem Hcl Injection Pharmacokinetics
See Literature
Diltiazem Hcl Injection Interactions
Interactions
See Contraindications. Possible bradycardia, AV block, and/or depression of contractility with concomitant oral β-blockers. Additive effects with agents known to affect cardiac conduction. Avoid concomitant CYP3A4 inducers (eg, rifampin). Potentiated by cimetidine; may need to adjust diltiazem dose. May potentiate anesthetics, benzodiazepines, buspirone, carbamazepine, cyclosporine, quinidine; monitor.
Diltiazem Hcl Injection Adverse Reactions
Adverse Reactions
Hypotension, inj site reactions (eg, itching, burning), vasodilation, arrhythmia; dermatological events (eg, erythema multiforme, exfoliative dermatitis; discontinue if occurs), hepatotoxicity, ventricular premature beats.
Diltiazem Hcl Injection Clinical Trials
See Literature
Diltiazem Hcl Injection Note
Notes
Formerly known under the brand name Cardizem.
Diltiazem Hcl Injection Patient Counseling
See Literature
