Share on Facebook
Share on Twitter
Share on LinkedIn
Share by Email
Print
Digoxin Oral Solution Generic Name & Formulations
Legal Class
Rx
General Description
Digoxin 0.05mg; per mL; lime-flavored; contains alcohol 10%.
Pharmacological Class
Cardiac glycoside.
How Supplied
Soln—60mL
Manufacturer
Digoxin Oral Solution Indications
Indications
Mild-to-moderate heart failure (with a diuretic and an ACE inhibitor when possible). Increase myocardial contractility in pediatrics with heart failure. Control of ventricular response rate in chronic atrial fibrillation.
Digoxin Oral Solution Dosage and Administration
Adult
Individualize: see full labeling. Initially 0.003mg/kg per day. Monitor digoxin levels.
Children
Individualize: see full labeling. >2yrs: initially 0.01mg/kg per day. Monitor digoxin levels.
Digoxin Oral Solution Contraindications
Contraindications
Ventricular fibrillation.
Digoxin Oral Solution Boxed Warnings
Not Applicable
Digoxin Oral Solution Warnings/Precautions
Warnings/Precautions
Renal dysfunction: reduce dose. Sinus node disease. Incomplete AV block. Accessory AV pathway (Wolff-Parkinson-White syndrome). Heart failure with preserved LV ejection fraction (eg, restrictive cardiomyopathy, constrictive pericarditis, amyloid heart disease, acute cor pulmonale, hypertrophic cardiomyopathy). Electrical cardioversion. Acute MI. Avoid in myocarditis. Toxicity risk increased by hypokalemia, hypomagnesemia, hypercalcemia, diabetes. Hypocalcemia may nullify effects. Thyroid disease. Hypermetabolic states. Monitor digoxin levels, electrolytes, renal function. Elderly. Children. Infants. Pregnancy (Cat.C). Nursing mothers.
Digoxin Oral Solution Pharmacokinetics
See Literature
Digoxin Oral Solution Interactions
Interactions
Toxicity risk increased by potassium-depleting drugs (eg, diuretics, amphotericin B, corticosteroids). Digoxin levels increased by antibiotics (eg, macrolides, tetracyclines), amiodarone, dronedarone, propafenone, quinidine, quinine, ritonavir, verapamil, indomethacin, itraconazole, lapatinib, mirabegron, spironolactone, telaprevir, drugs that reduce GI motility (eg, propantheline, diphenoxylate), thyroid antagonists, drugs that reduce renal function, others. Digoxin levels decreased by thyroid hormones, antacids, kaolin-pectin, cholestyramine, neomycin, penicillamine, rifampin, sulfasalazine, drugs that increase GI motility (eg, metoclopramide), certain antineoplastics, others. Digoxin levels possibly affected by alprazolam, cyclosporine, diclofenac, others. Arrhythmias with sympathomimetics, succinylcholine, or rapid calcium infusion. Heart block with drugs that affect cardiac conduction (eg, calcium channel blockers, β-blockers). Increased risk of bradycardia with ivabradine.
Digoxin Oral Solution Adverse Reactions
Adverse Reactions
GI upset, anorexia, CNS effects (eg, blurred or yellow vision, or mental disturbances, confusion, headache, weakness, dizziness, apathy), gynecomastia, rash, heart block, arrhythmias (esp. children).
Digoxin Oral Solution Clinical Trials
See Literature
Digoxin Oral Solution Note
Not Applicable
Digoxin Oral Solution Patient Counseling
See Literature
