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Dibenzyline Generic Name & Formulations
Legal Class
Rx
General Description
Phenoxybenzamine HCl 10mg; caps.
Pharmacological Class
Alpha adrenergic blocker.
How Supplied
Caps—100
Manufacturer
Dibenzyline Indications
Indications
Treatment of pheochromocytoma, to control episodes of hypertension and sweating. May use concomitant β-blocker if tachycardia is excessive.
Dibenzyline Dosage and Administration
Adult
Individualize. Initially 10mg twice daily. Increase dose every other day, usually to 20–40mg 2 or 3 times daily, until optimal dose obtained. Observe patients after each increase before instituting another increase.
Children
Not recommended.
Dibenzyline Contraindications
Contraindications
Conditions where a fall in BP may be undesirable.
Dibenzyline Boxed Warnings
Not Applicable
Dibenzyline Warnings/Precautions
Warnings/Precautions
Cerebral or coronary arteriosclerosis. Renal damage. May aggravate respiratory infections. Pregnancy (Cat.C). Nursing mothers: not recommended.
Dibenzyline Pharmacokinetics
See Literature
Dibenzyline Interactions
Interactions
Concomitant drugs that stimulate both alpha- and beta-adrenergic receptors (eg, epinephrine) may produce exaggerated hypotensive response and tachycardia. Blocks hyperthermia production by levarterenol. Blocks hypothermia production by reserpine.
Dibenzyline Adverse Reactions
Adverse Reactions
Postural hypotension, tachycardia, inhibition of ejaculation, nasal congestion, miosis, GI upset, drowsiness, fatigue. May be carcinogenic (w. long-term use: not recommended).
Dibenzyline Clinical Trials
See Literature
Dibenzyline Note
Not Applicable
Dibenzyline Patient Counseling
See Literature
