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Demser Generic Name & Formulations
Legal Class
Rx
General Description
Metyrosine 250mg; caps.
Pharmacological Class
Tyrosine hydroxylase inhibitor.
How Supplied
Caps—100
Manufacturer
Demser Indications
Indications
Treatment of pheochromocytoma for: preoperative preparation for surgery; or management when surgery is contraindicated. Chronic treatment in malignant pheochromocytoma.
Demser Dosage and Administration
Adult
Initially 250mg 4 times daily; may increase by 250–500mg daily up to max 4g/day in divided doses. Usual dose: 2–3g/day; monitor. If hypertensive, titrate dose to normalize BP and control symptoms; if normotensive, titrate dose to reduce urinary metanephrines and/or vanillylmandelic acid by ≥50%. Add an α-blocker (eg, phenoxybenzamine) if patients not adequately controlled. Pre-op prep: treat for at least 5–7 days.
Children
Not recommended.
Demser Contraindications
Not Applicable
Demser Boxed Warnings
Not Applicable
Demser Warnings/Precautions
Warnings/Precautions
Renal or hepatic impairment. Maintain adequate hydration; if crystalluria occurs, increase more fluids; if crystalluria persists, reduce dose or discontinue. Pre-op use: maintain adequate intravascular volume intra- and postoperatively. Pregnancy (Cat.C). Nursing mothers.
Demser Pharmacokinetics
See Literature
Demser Interactions
Interactions
Increased CNS effects with alcohol, other CNS depressants (eg, hypnotics, sedatives, tranquilizers). Potentiates extrapyramidal effects of phenothiazines, haloperidol.
Demser Adverse Reactions
Adverse Reactions
Sedation, diarrhea, extrapyramidal effects, anxiety, CNS disturbances, crystalluria; rare: hematological disorders.
Demser Clinical Trials
See Literature
Demser Note
Not Applicable
Demser Patient Counseling
See Literature
