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Corlopam Generic Name & Formulations
Legal Class
Rx
General Description
Fenoldopam mesylate 10mg/mL; soln for IV infusion after dilution; contains sodium metabisulfite.
Pharmacological Class
Dopamine D1-like receptor agonist.
How Supplied
Single-dose vial (1mL, 2mL)—1
Manufacturer
Generic Availability
YES
Corlopam Indications
Indications
Adults: for the in-hospital, short-term (up to 48hrs) management of severe hypertension when rapid, but quickly reversible, emergency reduction of blood pressure is clinically indicated, including malignant hypertension with deteriorating end-organ function. Children: for the in-hospital, short-term (up to 4hrs) reduction in blood pressure.
Corlopam Dosage and Administration
Adult
Give by continuous IV infusion. Doses from 0.01–1.6mcg/kg/min have been studied. Initial dose should be titrated upward or downward, no more frequently than every 15mins (and less frequently as goal pressure is approached) to achieve desired therapeutic effect. The recommended increments for titration are 0.05–0.1mcg/kg/min.
Children
Give by continuous infusion pump appropriate for delivery of low infusion rates. Usual starting dose: 0.2mcg/kg/min; increased dosages of up to 0.3–0.5mcg/kg/min every 20–30mins were generally well tolerated.
Corlopam Contraindications
Not Applicable
Corlopam Boxed Warnings
Not Applicable
Corlopam Warnings/Precautions
Warnings/Precautions
Sulfite sensitivity. Glaucoma. Intraocular hypertension. Increased intracranial pressure. Acute cerebral infarction. Hemorrhage. Monitor BP, electrolytes. Pregnancy. Nursing mothers: not recommended.
Corlopam Pharmacokinetics
See Literature
Corlopam Interactions
Interactions
Avoid concomitant β-blockers.
Corlopam Adverse Reactions
Adverse Reactions
Headache, flushing, nausea, hypotension, tachycardia, hypokalemia.
Corlopam Clinical Trials
See Literature
Corlopam Note
Not Applicable
Corlopam Patient Counseling
See Literature
