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Chlorthalidone Generic Name & Formulations
Legal Class
Rx
General Description
Chlorthalidone 25mg, 50mg; tabs.
Pharmacological Class
Diuretic (monosulfamyl).
How Supplied
Contact supplier.
Manufacturer
Mechanism of Action
Chlorthalidone is an oral diuretic with prolonged action and low toxicity. It produces copious diuresis with greatly increased excretion of sodium and chloride. The site of action appears to be the cortical diluting segment of the ascending limb of Henle’s loop of the nephron.
Chlorthalidone Indications
Indications
Edema.
Chlorthalidone Dosage and Administration
Adult
Initially 50–100mg daily or 100mg on alternate days. Some may require 150–200mg at these intervals or up to 200mg daily. Maintenance: doses often lower than initial doses; individualize.
Children
Not established.
Chlorthalidone Contraindications
Contraindications
Anuria. Sulfonamide allergy.
Chlorthalidone Boxed Warnings
Not Applicable
Chlorthalidone Warnings/Precautions
Warnings/Precautions
Renal or hepatic impairment. Diabetes. Gout. Asthma. SLE. Postsympathectomy. Volume depletion. Salt restriction. Monitor electrolytes; discontinue if electrolyte abnormalities develop. Metabolic disturbances. Pregnancy. Nursing mothers: not recommended.
Chlorthalidone Pharmacokinetics
Elimination
Renal. Half-life: 40 hours (50–200 mg).
Chlorthalidone Interactions
Interactions
Digitalis, lithium toxicity. Adjust antidiabetic, antigout medications. ACTH, corticosteroids, amphotericin B increase hypokalemia risk. Orthostatic hypotension with alcohol, CNS depressants. May potentiate nondepolarizing muscle relaxants, other antihypertensives (eg, ganglionic or peripheral adrenergic blocking agents). May antagonize norepinephrine. May interfere with parathyroid tests.
Chlorthalidone Adverse Reactions
Adverse Reactions
Electrolyte abnormalities (esp. hypokalemia), hyperglycemia, hyperuricemia, photosensitivity, orthostatic hypotension, GI disturbances, CNS reactions (eg, dizziness), hematologic reactions (eg, thrombocytopenia).
Chlorthalidone Clinical Trials
See Literature
Chlorthalidone Note
Notes
Formerly known under the brand name Hygroton.
Chlorthalidone Patient Counseling
See Literature
Chlorthalidone Generic Name & Formulations
Legal Class
Rx
General Description
Chlorthalidone 25mg, 50mg; tabs.
Pharmacological Class
Diuretic (monosulfamyl).
How Supplied
Contact supplier.
Manufacturer
Mechanism of Action
Chlorthalidone is an oral diuretic with prolonged action and low toxicity. It produces copious diuresis with greatly increased excretion of sodium and chloride. The site of action appears to be the cortical diluting segment of the ascending limb of Henle’s loop of the nephron.
Chlorthalidone Indications
Indications
Hypertension.
Chlorthalidone Dosage and Administration
Adult
Initially 25mg once daily; if needed may increase to 50mg once daily. If additional control needed, increase to 100mg once daily or add second antihypertensive. Maintenance: doses may be lower than initial doses; individualize.
Children
Not established.
Chlorthalidone Contraindications
Contraindications
Anuria. Sulfonamide allergy.
Chlorthalidone Boxed Warnings
Not Applicable
Chlorthalidone Warnings/Precautions
Warnings/Precautions
Renal or hepatic impairment. Diabetes. Gout. Asthma. SLE. Postsympathectomy. Volume depletion. Salt restriction. Monitor electrolytes; discontinue if electrolyte abnormalities develop. Metabolic disturbances. Pregnancy. Nursing mothers: not recommended.
Chlorthalidone Pharmacokinetics
Elimination
Renal. Half-life: 40 hours (50–200 mg).
Chlorthalidone Interactions
Interactions
Digitalis, lithium toxicity. Adjust antidiabetic, antigout medications. ACTH, corticosteroids, amphotericin B increase hypokalemia risk. Orthostatic hypotension with alcohol, CNS depressants. May potentiate nondepolarizing muscle relaxants, other antihypertensives (eg, ganglionic or peripheral adrenergic blocking agents). May antagonize norepinephrine. May interfere with parathyroid tests.
Chlorthalidone Adverse Reactions
Adverse Reactions
Electrolyte abnormalities (esp. hypokalemia), hyperglycemia, hyperuricemia, photosensitivity, orthostatic hypotension, GI disturbances, CNS reactions (eg, dizziness), hematologic reactions (eg, thrombocytopenia).
Chlorthalidone Clinical Trials
See Literature
Chlorthalidone Note
Notes
Formerly known under the brand name Hygroton.
Chlorthalidone Patient Counseling
See Literature
