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Cardura Generic Name & Formulations
Legal Class
Rx
General Description
Doxazosin (as mesylate) 1mg, 2mg, 4mg, 8mg; scored tabs.
Pharmacological Class
Alpha-1 blocker.
How Supplied
Tabs—100
Manufacturer
Cardura Indications
Indications
Benign prostatic hyperplasia (BPH).
Cardura Dosage and Administration
Adult
Initially 1mg once daily; may double dose every 1–2 weeks; max 8mg/day.
Children
Not applicable.
Cardura Contraindications
Not Applicable
Cardura Boxed Warnings
Not Applicable
Cardura Warnings/Precautions
Warnings/Precautions
Severe hepatic impairment: not recommended. Monitor blood pressure and for orthostatic hypotension initially and if dose increased. Syncope. Cataract surgery (intraoperative floppy iris syndrome possible). Exclude prostate cancer.
Cardura Pharmacokinetics
Elimination
Fecal (63%); urine (9%). Half-life: ~22hrs.
Cardura Interactions
Not Applicable
Cardura Adverse Reactions
Adverse Reactions
Dizziness, fatigue, hypotension, edema, dyspnea; rare: priapism.
Cardura Clinical Trials
See Literature
Cardura Note
Not Applicable
Cardura Patient Counseling
See Literature
Cardura Generic Name & Formulations
Legal Class
Rx
General Description
Doxazosin (as mesylate) 1mg, 2mg, 4mg, 8mg; scored tabs.
Pharmacological Class
Alpha-1 blocker.
How Supplied
Tabs—100
Manufacturer
Cardura Indications
Indications
Hypertension.
Cardura Dosage and Administration
Adult
Initially 1 mg once daily. Titrate gradually (based on standing BP at 2–6 hours and 24 hours post-dose) at 2-week intervals if needed; max 16 mg/day.
Children
Not established.
Cardura Contraindications
Not Applicable
Cardura Boxed Warnings
Not Applicable
Cardura Warnings/Precautions
Warnings/Precautions
Severe hepatic impairment: not recommended. Monitor for orthostatic hypotension initially and if dose increased. Cataract surgery (intraoperative floppy iris syndrome possible). Pregnancy (Cat.C). Nursing mothers.
Cardura Pharmacokinetics
Elimination
Fecal (63%); urine (9%). Half-life: ~22hrs.
Cardura Interactions
Interactions
Caution when adding other antihypertensives.
Cardura Adverse Reactions
Adverse Reactions
Syncope (esp. 1st dose and with increased doses), dizziness, somnolence, fatigue/malaise, edema, rhinitis, abnormal vision, tinnitus, epistaxis, orthostatic hypotension, sexual dysfunction, polyuria, urinary incontinence, ataxia, leukopenia, neutropenia, arrhythmia; rare: priapism.
Cardura Clinical Trials
See Literature
Cardura Note
Not Applicable
Cardura Patient Counseling
See Literature
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