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Biorphen Generic Name & Formulations
Legal Class
Rx
General Description
Phenylephrine HCl 0.1mg/mL; soln for IV inj.
Pharmacological Class
Sympathomimetic.
How Supplied
Ampules (5mL)—10
Manufacturer
Biorphen Indications
Indications
Treatment of clinically important hypotension resulting primarily from vasodilation in the setting of anesthesia.
Biorphen Dosage and Administration
Adult
Initially 40–100mcg by IV bolus, additional doses may be administered every 1–2 minutes as needed; up to max total dose of 200mcg.
Children
Not established.
Biorphen Contraindications
Not Applicable
Biorphen Boxed Warnings
Not Applicable
Biorphen Warnings/Precautions
Warnings/Precautions
Exacerbation of angina (in those with severe arteriosclerosis or history of angina). Heart failure. Pulmonary arterial hypertension. Extensive peripheral vascular disease. Monitor renal function. ESRD. Autonomic dysfunction (eg, spinal cord injury). Avoid extravasation. Elderly. Pregnancy. Nursing mothers.
Biorphen Pharmacokinetics
See Literature
Biorphen Interactions
Interactions
Potentiated by oxytocic drugs, tricyclic antidepressants, MAOIs, angiotensin, aldosterone, atropine, steroids, norepinephrine transporter inhibitors, ergot derivatives. Antagonized by alpha-adrenergic antagonists, PDE-5 inhibitors, mixed alpha- and beta-receptor antagonists, calcium channel blockers (eg, nifedipine), benzodiazepines, ACE inhibitors, reserpine, guanfacine.
Biorphen Adverse Reactions
Adverse Reactions
Nausea, vomiting, headache; vasoconstriction, ischemia, severe bradycardia, renal toxicity.
Biorphen Clinical Trials
See Literature
Biorphen Note
Not Applicable
Biorphen Patient Counseling
See Literature
