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Avapro Generic Name & Formulations
Legal Class
Rx
General Description
Irbesartan 75mg, 150mg, 300mg; tabs.
Pharmacological Class
Angiotensin II receptor blocker (ARB).
How Supplied
Tabs 75mg—90; 150mg, 300mg—30
Manufacturer
Generic Availability
YES
Avapro Indications
Indications
Diabetic nephropathy in patients with type 2 diabetes and hypertension.
Avapro Dosage and Administration
Adult
300mg once daily.
Children
Not recommended.
Avapro Contraindications
Contraindications
Concomitant aliskiren in patients with diabetes.
Avapro Boxed Warnings
Boxed Warning
Fetal toxicity.
Avapro Warnings/Precautions
Warnings/Precautions
Fetal toxicity may develop; discontinue if pregnancy is detected. Correct salt/volume depletion before beginning therapy, or reduce initial dose. Renal impairment: monitor. Severe CHF. Renal artery stenosis. Elderly. Neonates. Pregnancy: avoid. Nursing mothers: not recommended.
Avapro Pharmacokinetics
See Literature
Avapro Interactions
Interactions
Hyperkalemia with K+ supplements, K+ sparing diuretics, K+-containing salt substitutes. May increase lithium levels; monitor. May be antagonized by, and renal toxicity potentiated by, NSAIDs, including selective COX-2 inhibitors (monitor renal function periodically in elderly and/or volume depleted). Dual inhibition of the renin-angiotensin system with ARBs, ACEIs, or aliskiren may increase risk of hypotension, hyperkalemia, renal function changes; monitor closely. Concomitant aliskiren in renal impairment (CrCl <60mL/min): not recommended.
Avapro Adverse Reactions
Adverse Reactions
Diarrhea, dyspepsia, fatigue, orthostatic hypotension; increased liver function tests, anemia, hyperkalemia, tinnitus.
Avapro Clinical Trials
See Literature
Avapro Note
Not Applicable
Avapro Patient Counseling
See Literature
Avapro Generic Name & Formulations
Legal Class
Rx
General Description
Irbesartan 75mg, 150mg, 300mg; tabs.
Pharmacological Class
Angiotensin II receptor blocker (ARB).
How Supplied
Tabs 75mg—90; 150mg, 300mg—30
Manufacturer
Generic Availability
YES
Avapro Indications
Indications
Hypertension.
Avapro Dosage and Administration
Adult
≥16yrs: 150mg once daily; may increase to 300mg once daily. Or, may add a low dose of diuretic. Salt/volume depletion: initially 75mg once daily.
Children
Not recommended.
Avapro Contraindications
Contraindications
Concomitant aliskiren in patients with diabetes.
Avapro Boxed Warnings
Boxed Warning
Fetal toxicity.
Avapro Warnings/Precautions
Warnings/Precautions
Fetal toxicity may develop; discontinue if pregnancy is detected. Correct salt/volume depletion before beginning therapy, or reduce initial dose. Renal impairment: monitor. Severe CHF. Renal artery stenosis. Elderly. Neonates. Pregnancy: avoid. Nursing mothers: not recommended.
Avapro Pharmacokinetics
See Literature
Avapro Interactions
Interactions
Hyperkalemia with K+ supplements, K+ sparing diuretics, K+-containing salt substitutes. May increase lithium levels; monitor. May be antagonized by, and renal toxicity potentiated by, NSAIDs, including selective COX-2 inhibitors (monitor renal function periodically in elderly and/or volume depleted). Dual inhibition of the renin-angiotensin system with ARBs, ACEIs, or aliskiren may increase risk of hypotension, hyperkalemia, renal function changes; monitor closely. Concomitant aliskiren in renal impairment (CrCl <60mL/min): not recommended.
Avapro Adverse Reactions
Adverse Reactions
Diarrhea, dyspepsia, fatigue, dizziness, hyperkalemia.
Avapro Clinical Trials
See Literature
Avapro Note
Not Applicable
Avapro Patient Counseling
See Literature
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