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Atacand Hct Generic Name & Formulations
Legal Class
Rx
General Description
Candesartan cilexetil, hydrochlorothiazide; 16mg/12.5mg, 32mg/12.5mg, 32mg/25mg; scored tabs.
Pharmacological Class
Angiotensin II receptor blocker (ARB) + thiazide diuretic.
How Supplied
Tabs—90
Manufacturer
Generic Availability
YES
Atacand Hct Indications
Indications
Hypertension.
Atacand Hct Dosage and Administration
Adult
Not for initial therapy. May be substituted for titrated components. BP not controlled on HCTZ 25mg once daily, or controlled but serum potassium decreased: one Atacand HCT 16/12.5mg tab once daily. BP not controlled on candesartan 32mg per day: initially one Atacand HCT 32/12.5mg tab once daily; may increase to 32/25mg once daily. Moderate to severe hepatic impairment or CrCl ≤30mL/min: not recommended.
Children
Not established.
Atacand Hct Contraindications
Contraindications
Anuria. Sulfonamide allergy. Concomitant aliskiren in patients with diabetes.
Atacand Hct Boxed Warnings
Boxed Warning
Fetal toxicity.
Atacand Hct Warnings/Precautions
Warnings/Precautions
Fetal toxicity may develop; discontinue if pregnancy is detected. Correct hypovolemia before starting, or monitor closely. Hepatic or renal impairment. Renal artery stenosis. CHF. Asthma. Diabetes. SLE. Gout. Surgery. Acute myopia. Secondary angle-closure glaucoma. Hypercalcemia: avoid. Monitor renal function and electrolytes periodically. Elderly. Neonates. Pregnancy (Cat.D); monitor. Nursing mothers: not recommended.
Atacand Hct Pharmacokinetics
See Literature
Atacand Hct Interactions
Interactions
See Contraindications. Dual inhibition of the renin-angiotensin system with ARBs, ACEIs, or aliskiren may increase risk of hypotension, hyperkalemia, renal function changes; monitor closely. Avoid concomitant aliskiren in renal impairment (CrCl <60mL/min). Digitalis, lithium toxicity (monitor). Adjust antidiabetic, antigout medications. Hyperkalemia with K+ supplements, K+ sparing diuretics, K+ containing salt substitutes. Hypokalemia with corticosteroids, ACTH. Orthostatic hypotension potentiated by alcohol, CNS depressants. May be antagonized by, and renal toxicity potentiated by NSAIDs, including selective COX-2 inhibitors; monitor. Potentiates other antihypertensives. May potentiate nondepolarizing muscle relaxants, diazoxide, cyclophosphamide, methotrexate. Concomitant cyclosporine may increase risk of hyperuricemia. Separate dosing by ≥4hrs before or 4–6hrs after cholestyramine or colestipol resins. May antagonize noradrenaline. May interfere with parathyroid tests.
Atacand Hct Adverse Reactions
Adverse Reactions
Upper RTI, back pain, dizziness, flu-like symptoms; hypotension, renal dysfunction, electrolyte and metabolic disturbances, rhabdomyolysis (rare); HCTZ: increased risk for non-melanoma skin cancer.
Atacand Hct Clinical Trials
See Literature
Atacand Hct Note
Not Applicable
Atacand Hct Patient Counseling
See Literature
