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Aspirin/dipyridamole Generic Name & Formulations
Legal Class
Rx
General Description
Aspirin 25mg (immediate-release), dipyridamole 200mg (extended-release); caps.
Pharmacological Class
Combination antiplatelet.
How Supplied
Contact supplier
Manufacturer
Aspirin/dipyridamole Indications
Indications
To reduce the risk of stroke in patients who have had transient ischemia of the brain or completed ischemic stroke due to thrombosis.
Aspirin/dipyridamole Dosage and Administration
Adult
Swallow whole. 1 cap twice daily, one in the morning and one in the evening. Alternative regimen in case of intolerable headaches: switch to 1 cap at bedtime and low-dose aspirin in AM; return to usual regimen as soon as possible, usually within 1 week.
Children
Not recommended.
Aspirin/dipyridamole Contraindications
Contraindications
NSAID allergy. Patients with the syndrome of asthma, rhinitis, and nasal polyps. Viral infection in children/teens (risk of Reye syndrome).
Aspirin/dipyridamole Boxed Warnings
Not Applicable
Aspirin/dipyridamole Warnings/Precautions
Warnings/Precautions
Not interchangeable with individual components of aspirin and dipyridamole. Increased risk of bleeding, including GI bleed. History of active peptic ulcer, severe hepatic or renal dysfunction (GFR <10mL/min); avoid. Coronary artery disease. Pre-existing hypotension. Chronic, heavy alcohol use. Labor & delivery. Pregnancy. Nursing mothers.
Aspirin/dipyridamole Pharmacokinetics
See Literature
Aspirin/dipyridamole Interactions
Interactions
Increased risk of bleeding with anticoagulants, antiplatelets, heparin, anagrelide, fibrinolytic therapy, alcohol, chronic NSAID use. Potentiates adenosine, acetazolamide, methotrexate, oral hypoglycemics. May antagonize ACE inhibitors, β-blockers, diuretics, cholinesterase inhibitors, uricosurics. May increase risk of renal dysfunction with NSAIDs. Monitor phenytoin, valproic acid, other anticonvulsants. Interrupt aspirin/dipyridamole dosing for 48hrs prior to stress testing using IV dipyridamole or other adenosinergic agents.
Aspirin/dipyridamole Adverse Reactions
Adverse Reactions
Headache, dyspepsia, abdominal pain, nausea, diarrhea; bleeding risk, increased liver enzymes, hepatic failure.
Aspirin/dipyridamole Clinical Trials
See Literature
Aspirin/dipyridamole Note
Notes
Formerly known under the brand name Aggrenox.
Aspirin/dipyridamole Patient Counseling
See Literature
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