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Amiloride/hctz Generic Name & Formulations
Legal Class
Rx
General Description
Amiloride HCl 5mg, hydrochlorothiazide 50mg; scored tabs.
Pharmacological Class
Diuretic (K+ sparing) + (thiazide).
How Supplied
Contact supplier
Manufacturer
Amiloride/hctz Indications
Indications
Edema when normokalemia is important.
Amiloride/hctz Dosage and Administration
Adult
Initially 1 tab daily with food; may increase to 2 tabs daily in single or divided doses. After initial diuresis, reassess therapy; may be given intermittently for maintenance.
Children
Not established.
Amiloride/hctz Contraindications
Contraindications
Concomitant triamterene, spironolactone, salt substitutes, K+ supplements (unless hypokalemia is severe). Hyperkalemia. Anuria. Diabetic nephropathy. Renal impairment. Sulfonamide allergy.
Amiloride/hctz Boxed Warnings
Not Applicable
Amiloride/hctz Warnings/Precautions
Warnings/Precautions
Acidosis predisposition. Electrolyte imbalance. Hepatic impairment. Monitor electrolytes, renal function (esp. in diabetics). Discontinue if serum potassium >5.5mEq/L or renal values progress. Gout. SLE. Severely ill. Elderly. Pregnancy (Cat.B). Nursing mothers: not recommended.
Amiloride/hctz Pharmacokinetics
See Literature
Amiloride/hctz Interactions
Interactions
Avoid lithium, spironolactone, triamterene, other K+-sparing diuretics, K+ supplements. Hyperkalemia with ACE inhibitors, NSAIDs. Hypokalemia with amphotericin B, corticosteroids, ACTH. Potentiated by CNS depressants. May potentiate nondepolarizing muscle relaxants. Antagonized by NSAIDs. May interfere with glucose tolerance or parathyroid test.
Amiloride/hctz Adverse Reactions
Adverse Reactions
Headache, weakness, GI upset, rash, dizziness, hyperkalemia, fatigue, arrhythmia, pruritus, leg ache, dyspnea, syncope, orthostatic hypotension, electrolyte imbalances, insomnia, depression, nasal congestion, impotence, photosensitivity, cough, hyperglycemia, hyperuricemia, adverse lipid values.
Amiloride/hctz Clinical Trials
See Literature
Amiloride/hctz Note
Notes
Formerly known under the brand name Moduretic.
Amiloride/hctz Patient Counseling
See Literature
Amiloride/hctz Generic Name & Formulations
Legal Class
Rx
General Description
Amiloride HCl 5mg, hydrochlorothiazide 50mg; scored tabs.
Pharmacological Class
Diuretic (K+ sparing) + (thiazide).
How Supplied
Contact supplier
Manufacturer
Amiloride/hctz Indications
Indications
Hypertension when normokalemia is important.
Amiloride/hctz Dosage and Administration
Adult
Initially 1 tab daily with food. May increase to 2 tabs daily in single or divided doses.
Children
Not established.
Amiloride/hctz Contraindications
Contraindications
Concomitant triamterene, spironolactone, salt substitutes, K+ supplements (unless hypokalemia is severe). Hyperkalemia. Anuria. Diabetic nephropathy. Renal impairment. Sulfonamide allergy.
Amiloride/hctz Boxed Warnings
Not Applicable
Amiloride/hctz Warnings/Precautions
Warnings/Precautions
Acidosis predisposition. Electrolyte imbalance. Hepatic impairment. Monitor electrolytes, renal function (esp. in diabetics). Discontinue if serum potassium >5.5mEq/L or renal values progress. Gout. SLE. Severely ill. Elderly. Pregnancy (Cat.B). Nursing mothers: not recommended.
Amiloride/hctz Pharmacokinetics
See Literature
Amiloride/hctz Interactions
Interactions
Avoid lithium, spironolactone, triamterene, other K+-sparing diuretics, K+ supplements. Hyperkalemia with ACE inhibitors, NSAIDs. Hypokalemia with amphotericin B, corticosteroids, ACTH. Potentiated by CNS depressants. May potentiate nondepolarizing muscle relaxants. Antagonized by NSAIDs. May interfere with glucose tolerance or parathyroid test.
Amiloride/hctz Adverse Reactions
Adverse Reactions
Headache, weakness, GI upset, rash, dizziness, hyperkalemia, fatigue, arrhythmia, pruritus, leg ache, dyspnea, syncope, orthostatic hypotension, electrolyte imbalances, insomnia, depression, nasal congestion, impotence, photosensitivity, cough, hyperglycemia, hyperuricemia, adverse lipid values.
Amiloride/hctz Clinical Trials
See Literature
Amiloride/hctz Note
Notes
Formerly known under the brand name Moduretic.
Amiloride/hctz Patient Counseling
See Literature
