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Amiloride Generic Name & Formulations
Legal Class
Rx
General Description
Amiloride HCl 5mg; tabs.
Pharmacological Class
Diuretic (K+ sparing).
How Supplied
Contact supplier
Manufacturer
Amiloride Indications
Indications
Adjunct in edema where normokalemia is important.
Amiloride Dosage and Administration
Adult
Administer with kaliuretic and food. Initially 5mg/day; 5–10mg usually adequate. If hypokalemia persists, may increase to 15mg/day and then 20mg/day with careful electrolyte monitoring. After initial diuresis, reassess therapy; may be given intermittently for maintenance.
Children
Not established.
Amiloride Contraindications
Contraindications
Concomitant triamterene, spironolactone, salt substitutes, K+ supplements (unless hypokalemia is severe). Hyperkalemia. Renal impairment. Anuria. Diabetic nephropathy.
Amiloride Boxed Warnings
Not Applicable
Amiloride Warnings/Precautions
Warnings/Precautions
Acidosis predisposition. Electrolyte imbalance. Hepatic impairment. Monitor electrolytes, renal function (esp. in diabetics). Discontinue if serum potassium >5.5mEq/L or renal values progress. Severely ill. Elderly. Pregnancy (Cat.B). Nursing mothers: not recommended.
Amiloride Pharmacokinetics
See Literature
Amiloride Interactions
Interactions
Avoid lithium, spironolactone, triamterene, other K+-sparing diuretics, K+ supplements. Hyperkalemia more likely with ACE inhibitors, NSAIDs, cyclosporine, tacrolimus. Hyponatremia, hypochloremia with other diuretics. Antagonized by NSAIDs. May interfere with parathyroid or glucose tolerance test.
Amiloride Adverse Reactions
Adverse Reactions
Headache, GI upset, weakness, fatigue, hyperkalemia, muscle cramps, dizziness, encephalopathy, cough, dyspnea, impotence.
Amiloride Clinical Trials
See Literature
Amiloride Note
Notes
Formerly known under the brand name Midamor.
Amiloride Patient Counseling
See Literature
Amiloride Generic Name & Formulations
Legal Class
Rx
General Description
Amiloride HCl 5mg; tabs.
Pharmacological Class
Diuretic (K+ sparing).
How Supplied
Contact supplier
Manufacturer
Amiloride Indications
Indications
Adjunct in hypertension.
Amiloride Dosage and Administration
Adult
Administer with kaliuretic and food. Initially 5mg/day; 5–10mg usually adequate. If hypokalemia persists, may increase to 15mg/day and then 20mg/day with careful electrolyte monitoring.
Children
Not established.
Amiloride Contraindications
Contraindications
Concomitant triamterene, spironolactone, salt substitutes, K+ supplements (unless hypokalemia is severe). Hyperkalemia. Renal impairment. Anuria. Diabetic nephropathy.
Amiloride Boxed Warnings
Not Applicable
Amiloride Warnings/Precautions
Warnings/Precautions
Acidosis predisposition. Electrolyte imbalance. Hepatic impairment. Monitor electrolytes, renal function (esp. in diabetics). Discontinue if serum potassium >5.5mEq/L or renal values progress. Severely ill. Elderly. Pregnancy (Cat.B). Nursing mothers: not recommended.
Amiloride Pharmacokinetics
See Literature
Amiloride Interactions
Interactions
Avoid lithium, spironolactone, triamterene, other K+-sparing diuretics, K+ supplements. Hyperkalemia more likely with ACE inhibitors, NSAIDs, cyclosporine, tacrolimus. Hyponatremia, hypochloremia with other diuretics. Antagonized by NSAIDs. May interfere with parathyroid or glucose tolerance test.
Amiloride Adverse Reactions
Adverse Reactions
Headache, GI upset, weakness, fatigue, hyperkalemia, muscle cramps, dizziness, encephalopathy, cough, dyspnea, impotence.
Amiloride Clinical Trials
See Literature
Amiloride Note
Notes
Formerly known under the brand name Midamor.
Amiloride Patient Counseling
See Literature
