Aldactazide

— THERAPEUTIC CATEGORIES —
  • Edema
  • Hypertension
PAGE CONTENTS
  • Jump to Section
  • Generic Name & Formulations
  • Indications
  • Dosage and Administration
  • Contraindications
  • Boxed Warnings
  • Warnings/Precautions
  • Pharmacokinetics
  • Interactions
  • Adverse Reactions
  • Clinical Trials
  • Note
  • Patient Counseling

    • Aldactazide Generic Name & Formulations

    Legal Class

    Rx

    General Description

    Spironolactone, hydrochlorothiazide; 25mg/25mg, 50mg/50mg+; tabs; +scored.

    Pharmacological Class

    Diuretic (K+ sparing) + (thiazide).

    How Supplied

    Tabs—100

    Manufacturer

    Pfizer Inc.

    Aldactazide Indications

    Indications

    Edema.

    Aldactazide Dosage and Administration

    Adult

    Not for initial therapy. Usual maintenance: 100mg each of spironolactone and HCTZ daily in single or divided doses. Range: 25mg–200mg of each component daily based on response to initial titration.

    Children

    Not established.

    Aldactazide Contraindications

    Contraindications

    Anuria. Renal impairment. Hypercalcemia. Hyperkalemia. Addison’s disease. Sulfonamide allergy. Acute or severe hepatic failure.

    Aldactazide Boxed Warnings

    Not Applicable

    Aldactazide Warnings/Precautions

    Warnings/Precautions

    History of allergy or bronchial asthma. Hyponatremia. Gout. Diabetes. SLE. Postsympathectomy. Acute angle-closure glaucoma. Acute myopia and choroidal effusions. Monitor electrolytes periodically. Metabolic disturbances. Monitor calcium levels in hypercalcemia. Hepatic impairment. Severe renal disease. Elderly. Pregnancy. Nursing mothers: not recommended.

    Aldactazide Pharmacokinetics

    Elimination

    Renal. Half-life: ~1.4 hours (spironolactone), 4–5 hours (hydrochlorothiazide).

    Aldactazide Interactions

    Interactions

    Avoid K+ sparing diuretics, K+ supplements, K+ containing salt substitutes, lithium. Concomitant abiraterone in prostate cancer patients may increase PSA levels: not recommended. Hyperkalemia more likely with ACE inhibitors, ARBs, aldosterone blockers, NSAIDs, heparin, LMWH. Hypokalemia with corticosteroids, ACTH. Potentiates alcohol, barbiturates, narcotics, skeletal muscle relaxants, antihypertensives. Reduced response to pressor amines (eg, norepinephrine). May need to adjust insulin or oral hypoglycemic dosage. Caution with cholestyramine. May be antagonized by NSAIDs, acetylsalicylic acid. Digitalis toxicity. May interfere with parathyroid tests.

    Aldactazide Adverse Reactions

    Adverse Reactions

    Hyperkalemia, gynecomastia, diarrhea, vomiting, nausea, somnolence, dizziness, headache, rash, confusion, fever, ataxia, menstrual changes, gastric ulcers, electrolyte disorders (esp. hypokalemia, hypomagnesemia), hyperglycemia, hyperuricemia, blood dyscrasias, photosensitivity, orthostatic hypotension, adverse lipid values; HCTZ: increased risk for non-melanoma skin cancer.

    Aldactazide Clinical Trials

    See Literature

    Aldactazide Note

    Not Applicable

    Aldactazide Patient Counseling

    See Literature

    Aldactazide Generic Name & Formulations

    Legal Class

    Rx

    General Description

    Spironolactone, hydrochlorothiazide; 25mg/25mg, 50mg/50mg+; tabs; +scored.

    Pharmacological Class

    Diuretic (K+ sparing) + (thiazide).

    How Supplied

    Tabs—100

    Manufacturer

    Pfizer Inc.

    Aldactazide Indications

    Indications

    Hypertension.

    Aldactazide Dosage and Administration

    Adult

    Not for initial therapy. Usual maintenance: 50–100mg each of spironolactone and HCTZ daily in single or divided doses.

    Children

    Not established.

    Aldactazide Contraindications

    Contraindications

    Anuria. Renal impairment. Hypercalcemia. Hyperkalemia. Addison’s disease. Sulfonamide allergy. Acute or severe hepatic failure.

    Aldactazide Boxed Warnings

    Not Applicable

    Aldactazide Warnings/Precautions

    Warnings/Precautions

    History of allergy or bronchial asthma. Hyponatremia. Gout. Diabetes. SLE. Postsympathectomy. Acute angle-closure glaucoma. Acute myopia and choroidal effusions. Monitor electrolytes periodically. Metabolic disturbances. Monitor calcium levels in hypercalcemia. Hepatic impairment. Severe renal disease. Elderly. Pregnancy. Nursing mothers: not recommended.

    Aldactazide Pharmacokinetics

    Elimination

    Renal. Half-life: ~1.4 hours (spironolactone), 4–5 hours (hydrochlorothiazide).

    Aldactazide Interactions

    Interactions

    Avoid K+ sparing diuretics, K+ supplements, K+ containing salt substitutes, lithium. Concomitant abiraterone in prostate cancer patients may increase PSA levels: not recommended. Hyperkalemia more likely with ACE inhibitors, ARBs, aldosterone blockers, NSAIDs, heparin, LMWH. Hypokalemia with corticosteroids, ACTH. Potentiates alcohol, barbiturates, narcotics, skeletal muscle relaxants, antihypertensives. Reduced response to pressor amines (eg, norepinephrine). May need to adjust insulin or oral hypoglycemic dosage. Caution with cholestyramine. May be antagonized by NSAIDs, acetylsalicylic acid. Digitalis toxicity. May interfere with parathyroid tests.

    Aldactazide Adverse Reactions

    Adverse Reactions

    Hyperkalemia, gynecomastia, diarrhea, vomiting, nausea, somnolence, dizziness, headache, rash, confusion, fever, ataxia, menstrual changes, gastric ulcers, electrolyte disorders (esp. hypokalemia, hypomagnesemia), hyperglycemia, hyperuricemia, blood dyscrasias, photosensitivity, orthostatic hypotension, adverse lipid values; HCTZ: increased risk for non-melanoma skin cancer.

    Aldactazide Clinical Trials

    See Literature

    Aldactazide Note

    Not Applicable

    Aldactazide Patient Counseling

    See Literature

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