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Adenosine Vials Generic Name & Formulations
Legal Class
Rx
General Description
Adenosine 3mg/mL; soln for IV infusion; preservative-free.
Pharmacological Class
Nucleoside.
How Supplied
Contact supplier.
Manufacturer
Mechanism of Action
Adenosine slows conduction time through the A-V node, can interrupt the reentry pathways through the A-V node, and can restore normal sinus rhythm in patients with paroxysmal supraventricular tachycardia (PSVT), including PSVT associated with Wolff-Parkinson-White Syndrome.
Adenosine Vials Indications
Indications
Adjunct to thallium-201 myocardial perfusion scintigraphy in patients unable to undergo adequate exercise stress.
Adenosine Vials Dosage and Administration
Adult
Give peripherally as a continuous IV infusion. ≥18yrs: 140mcg/kg/min over 6 mins for a total dose of 0.84mg/kg. Infusion rate (mL/min)= 0.140 (mg/kg/min) x total body weight (kg)/adenosine conc. (3mg/mL). See full labeling.
Children
<18yrs: not established.
Adenosine Vials Contraindications
Contraindications
2nd- or 3rd-degree AV block or sinus node disease (eg, sick sinus syndrome, symptomatic bradycardia), unless paced. Bronchoconstructive or bronchospastic disease (eg, asthma).
Adenosine Vials Boxed Warnings
Not Applicable
Adenosine Vials Warnings/Precautions
Warnings/Precautions
Have resuscitative measures available. Increased risk of cardiovascular events in patients with acute MI, unstable angina, or cardiovascular instability; avoid use. Pre-existing 1st-degree AV block or bundle branch block. Discontinue if persistent or symptomatic high-grade AV block or hypotension occurs. Autonomic dysfunction. Stenotic valvular heart disease. Pericarditis or pericardial effusions. Stenotic carotid artery disease with cerebrovascular insufficiency. Hypovolemia. Obstructive lung disease (eg, emphysema, bronchitis). Discontinue if severe respiratory difficulties occur. Elderly. Pregnancy (Cat.C). Nursing mothers.
Adenosine Vials Pharmacokinetics
Elimination
Renal. Half-life: <10 seconds.
Adenosine Vials Interactions
Interactions
May be potentiated by β-blockers, cardiac glycosides, calcium channel blockers; use caution. Increased risk of seizures with concomitant methylxanthines (eg, caffeine, aminophylline, theophylline): not recommended. Potentiated by dipyridamole.
Adenosine Vials Adverse Reactions
Adverse Reactions
Flushing, chest discomfort, dyspnea, headache, throat/neck/jaw discomfort, GI discomfort, lightheadedness/dizziness; cardiac arrest, sustained ventricular tachycardia, MI, bronchoconstriction, hypo- or hypertension, cerebrovascular accident, convulsive seizures, atrial fibrillation.
Adenosine Vials Clinical Trials
See Literature
Adenosine Vials Note
Notes
Formerly known under the brand name Adenoscan.
Adenosine Vials Patient Counseling
See Literature
