Adenosine Prefilled Syringes Dosage & Rx Info

Adenosine Prefilled Syringes Generic Name & Formulations

Legal Class

General Description

Adenosine 3mg/mL; soln for IV inj; preservative-free.

Pharmacological Class

Nucleoside.

How Supplied

Contact supplier.

Manufacturer

Various generic manufacturers

Mechanism of Action

Adenosine slows conduction time through the A-V node, can interrupt the reentry pathways through the A-V node, and can restore normal sinus rhythm in patients with paroxysmal supraventricular tachycardia (PSVT), including PSVT associated with Wolff-Parkinson-White Syndrome.

Adenosine Prefilled Syringes Indications

Indications

Paroxysmal supraventricular tachycardia (PSVT), including that associated with accessory bypass tracts (Wolff-Parkinson-White Syndrome).

Adenosine Prefilled Syringes Dosage and Administration

Adult

Give peripherally by rapid bolus either directly into vein or through IV line (followed by saline flush) over 1–2 seconds. Initially 6mg; if no result within 1–2 mins, may give 12mg; may repeat a second 12mg dose if needed. Max 12mg/dose.

Children

<50kg: Give centrally or peripherally by rapid IV bolus, followed by saline flush. Initially 0.05–0.1mg/kg; if no conversion of PSVT within 1–2 mins, may give incrementally higher doses, increasing the amount by 0.05–0.1mg/kg. Continue until sinus rhythm is established, or max single dose of 0.3mg/kg is used. ≥50kg: as adult.

Adenosine Prefilled Syringes Contraindications

Contraindications

Sinus bradycardia. 2^nd- or 3^rd-degree AV block, sick sinus syndrome, unless paced.

Adenosine Prefilled Syringes Boxed Warnings

Not Applicable

Adenosine Prefilled Syringes Warnings/Precautions

Warnings/Precautions

Attempt vagal maneuvers, when clinically advisable, before administration. Discontinue if high-level heart block occurs. Avoid in asthma. Obstructive lung disease (eg, emphysema, bronchitis). Discontinue if severe respiratory difficulties occur. Elderly. Pregnancy (Cat.C).

Adenosine Prefilled Syringes Pharmacokinetics

Metabolism

Phosphorylation, deamination.

Elimination

Renal. Half-life: <10 seconds.

Adenosine Prefilled Syringes Interactions

Interactions

Concomitant digoxin +/– verapamil may cause ventricular fibrillation. Potentiated by dipyridamole. Antagonized by methylxanthines (eg, caffeine, theophylline). Carbamazepine may increase degree of heart block.

Adenosine Prefilled Syringes Adverse Reactions

Adverse Reactions

Facial flushing, dyspnea, chest pressure, nausea, headache, lightheadedness, numbness, arrhythmias at time of conversion; rare: ventricular fibrillation.

Adenosine Prefilled Syringes Clinical Trials

See Literature

Adenosine Prefilled Syringes Note

Notes

Formerly known under the brand name Adenocard.

Adenosine Prefilled Syringes Patient Counseling