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Promethazine Hcl Injection Generic Name & Formulations
Legal Class
Rx
General Description
Promethazine HCl 25mg/mL, 50mg/mL; sol for IM or IV inj; contains sulfites.
Pharmacological Class
Phenothiazine.
How Supplied
Contact supplier.
Manufacturer
Promethazine Hcl Injection Indications
Indications
Allergic reactions to blood or plasma. Uncomplicated allergic conditions of the immediate type where oral therapy is impossible or contraindicated. Adjunct in anaphylaxis.
Promethazine Hcl Injection Dosage and Administration
Adult
25mg IM or IV, if 2nd dose is needed, may repeat after 2 hours. Switch to oral form as soon as possible
Children
<2yrs: see Contraindications. ≥2yrs: should not exceed half that of suggested adult dose (see literature).
Promethazine Hcl Injection Contraindications
Contraindications
Children <2 years. Coma. Intra-arterial or subcutaneous injection.
Promethazine Hcl Injection Boxed Warnings
Not Applicable
Promethazine Hcl Injection Warnings/Precautions
Warnings/Precautions
Sulfite sensitivity. CNS depression. Impaired respiratory function (eg, COPD, sleep apnea). Narrow-angle glaucoma. GI or GU obstruction. Cardiovascular or liver disease. Seizure disorders. Peptic ulcer. Bone marrow depression. Elderly. Pregnancy (Cat.C). Labor & delivery. Nursing mothers: not recommended.
Promethazine Hcl Injection Pharmacokinetics
See Literature
Promethazine Hcl Injection Interactions
Interactions
Potentiates CNS depression with alcohol, other CNS depressants. Caution with epinephrine, anticholinergics, MAOIs. May alter hCG pregnancy test results and glucose tolerance tests.
Promethazine Hcl Injection Adverse Reactions
Adverse Reactions
Inj site reactions, CNS depression/drowsiness, lowered seizure threshold, cholestatic jaundice, anticholinergic and extrapyramidal effects, neuroleptic malignant syndrome, photosensitivity, hypo- or hypertension, rash, blood dyscrasias, nausea, dry mouth, paradoxical reactions; children: respiratory depression (may be fatal).
Promethazine Hcl Injection Clinical Trials
See Literature
Promethazine Hcl Injection Note
Notes
Formerly known under the brand name Phenergan.
Promethazine Hcl Injection Patient Counseling
See Literature
Promethazine Hcl Injection Generic Name & Formulations
Legal Class
Rx
General Description
Promethazine HCl 25mg/mL, 50mg/mL; sol for IM or IV inj; contains sulfites.
Pharmacological Class
Phenothiazine.
How Supplied
Contact supplier.
Manufacturer
Promethazine Hcl Injection Indications
Indications
Motion sickness. Prevention and treatment of nausea & vomiting with anesthesia and surgery.
Promethazine Hcl Injection Dosage and Administration
Adult
12.5–25mg IM or IV every 4 hours.
Children
<2yrs: see Contraindications. ≥2yrs: should not exceed half that of suggested adult dose (see literature). Should not be used in vomiting of unknown etiology in children and adolescents.
Promethazine Hcl Injection Contraindications
Contraindications
Children <2 years. Coma. Intra-arterial or subcutaneous injection.
Promethazine Hcl Injection Boxed Warnings
Not Applicable
Promethazine Hcl Injection Warnings/Precautions
Warnings/Precautions
Sulfite sensitivity. CNS depression. Impaired respiratory function (eg, COPD, sleep apnea). Narrow-angle glaucoma. GI or GU obstruction. Cardiovascular or liver disease. Seizure disorders. Peptic ulcer. Bone marrow depression. Elderly. Pregnancy (Cat.C). Labor & delivery. Nursing mothers: not recommended.
Promethazine Hcl Injection Pharmacokinetics
See Literature
Promethazine Hcl Injection Interactions
Interactions
Potentiates CNS depression with alcohol, other CNS depressants. Caution with epinephrine, anticholinergics, MAOIs. May alter hCG pregnancy test results and glucose tolerance tests.
Promethazine Hcl Injection Adverse Reactions
Adverse Reactions
Inj site reactions, CNS depression/drowsiness, lowered seizure threshold, cholestatic jaundice, anticholinergic and extrapyramidal effects, neuroleptic malignant syndrome, photosensitivity, hypo- or hypertension, rash, blood dyscrasias, nausea, dry mouth, paradoxical reactions; children: respiratory depression (may be fatal).
Promethazine Hcl Injection Clinical Trials
See Literature
Promethazine Hcl Injection Note
Notes
Formerly known under the brand name Phenergan.
Promethazine Hcl Injection Patient Counseling
See Literature
Promethazine Hcl Injection Generic Name & Formulations
Legal Class
Rx
General Description
Promethazine HCl 25mg/mL, 50mg/mL; sol for IM or IV inj; contains sulfites.
Pharmacological Class
Phenothiazine.
How Supplied
Contact supplier.
Manufacturer
Promethazine Hcl Injection Indications
Indications
Adjunct to analgesics for control of postoperative pain. Special surgical situations (i.e. bronchoscopy, ophthalmic surgery, poor risk patients) to reduce amounts of narcotic analgesic as an adjunct to anesthesia and analgesia.
Promethazine Hcl Injection Dosage and Administration
Adult
25–50mg IM or IV.
Children
<2yrs: see Contraindications. ≥2yrs: should not exceed half that of suggested adult dose (see literature).
Promethazine Hcl Injection Contraindications
Contraindications
Children <2 years. Coma. Intra-arterial or subcutaneous injection.
Promethazine Hcl Injection Boxed Warnings
Not Applicable
Promethazine Hcl Injection Warnings/Precautions
Warnings/Precautions
Sulfite sensitivity. CNS depression. Impaired respiratory function (eg, COPD, sleep apnea). Narrow-angle glaucoma. GI or GU obstruction. Cardiovascular or liver disease. Seizure disorders. Peptic ulcer. Bone marrow depression. Elderly. Pregnancy (Cat.C). Labor & delivery. Nursing mothers: not recommended.
Promethazine Hcl Injection Pharmacokinetics
See Literature
Promethazine Hcl Injection Interactions
Interactions
Potentiates CNS depression with alcohol, other CNS depressants. Caution with epinephrine, anticholinergics, MAOIs. May alter hCG pregnancy test results and glucose tolerance tests.
Promethazine Hcl Injection Adverse Reactions
Adverse Reactions
Inj site reactions, CNS depression/drowsiness, lowered seizure threshold, cholestatic jaundice, anticholinergic and extrapyramidal effects, neuroleptic malignant syndrome, photosensitivity, hypo- or hypertension, rash, blood dyscrasias, nausea, dry mouth, paradoxical reactions; children: respiratory depression (may be fatal).
Promethazine Hcl Injection Clinical Trials
See Literature
Promethazine Hcl Injection Note
Notes
Formerly known under the brand name Phenergan.
Promethazine Hcl Injection Patient Counseling
See Literature
Promethazine Hcl Injection Generic Name & Formulations
Legal Class
Rx
General Description
Promethazine HCl 25mg/mL, 50mg/mL; sol for IM or IV inj; contains sulfites.
Pharmacological Class
Phenothiazine.
How Supplied
Contact supplier.
Manufacturer
Promethazine Hcl Injection Indications
Indications
For light sedation and relief of apprehension. Obstetric (during labor), pre- and post-operative sedation.
Promethazine Hcl Injection Dosage and Administration
Adult
Sedation: 25–50mg IM or IV. Obstetric: 50mg IM or IV in early stages of labor; 25–75mg IM or IV when labor is established; may repeat once or twice at 4 hour intervals; max 100mg/day. Pre- and post-op: 25–50mg IM or IV.
Children
<2yrs: see Contraindications. ≥2yrs: should not exceed half that of suggested adult dose (see literature).
Promethazine Hcl Injection Contraindications
Contraindications
Children <2 years. Coma. Intra-arterial or subcutaneous injection.
Promethazine Hcl Injection Boxed Warnings
Not Applicable
Promethazine Hcl Injection Warnings/Precautions
Warnings/Precautions
Sulfite sensitivity. CNS depression. Impaired respiratory function (eg, COPD, sleep apnea). Narrow-angle glaucoma. GI or GU obstruction. Cardiovascular or liver disease. Seizure disorders. Peptic ulcer. Bone marrow depression. Elderly. Pregnancy (Cat.C). Labor & delivery. Nursing mothers: not recommended.
Promethazine Hcl Injection Pharmacokinetics
See Literature
Promethazine Hcl Injection Interactions
Interactions
Potentiates CNS depression with alcohol, other CNS depressants. Caution with epinephrine, anticholinergics, MAOIs. May alter hCG pregnancy test results and glucose tolerance tests.
Promethazine Hcl Injection Adverse Reactions
Adverse Reactions
Inj site reactions, CNS depression/drowsiness, lowered seizure threshold, cholestatic jaundice, anticholinergic and extrapyramidal effects, neuroleptic malignant syndrome, photosensitivity, hypo- or hypertension, rash, blood dyscrasias, nausea, dry mouth, paradoxical reactions; children: respiratory depression (may be fatal).
Promethazine Hcl Injection Clinical Trials
See Literature
Promethazine Hcl Injection Note
Notes
Formerly known under the brand name Phenergan.
Promethazine Hcl Injection Patient Counseling
See Literature
