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Epipen Generic Name & Formulations
Legal Class
Rx
General Description
Epinephrine 0.3mg (1:1000); prefilled auto-injector; contains sulfites.
Pharmacological Class
Sympathomimetic.
See Also
How Supplied
Packs—2
Manufacturer
Generic Availability
YES
Epipen Indications
Indications
Emergency treatment of allergic reactions (Type 1) including anaphylaxis.
Epipen Dosage and Administration
Adults and Children
Inject IM or SQ only into the anterolateral aspect of the thigh. <15kg: not studied. 15–30kg: 0.15mg. ≥30kg: 0.3mg. May repeat another dose if needed.
Epipen Contraindications
Not Applicable
Epipen Boxed Warnings
Not Applicable
Epipen Warnings/Precautions
Warnings/Precautions
The presence of sulfite in this product should not deter use. Cardiovascular disease. Hypertension. Hyperthyroidism. Diabetes. Parkinson's disease. Injection-related complications: do not inject intravenously or into buttock (risk of Clostridial infections), digits, hands, or feet; hold leg firmly and limit movement in children prior to and during injection. Advise patient to seek medical help immediately. Train patient in use of device. Elderly. Pregnancy. Nursing mothers.
Epipen Pharmacokinetics
See Literature
Epipen Interactions
Interactions
May be potentiated by MAOIs, tricyclic antidepressants, levothyroxine, antihistamines (eg, chlorpheniramine, tripelennamine, diphenhydramine). May be antagonized by β-blockers (eg, propranolol), α-blockers (eg, phentolamine), ergot alkaloids. Arrhythmias possible with cardiac glycosides, diuretics, or anti-arrhythmics.
Epipen Adverse Reactions
Adverse Reactions
Anxiety, apprehensiveness, restlessness, tremor, weakness, dizziness, sweating, palpitations, pallor, nausea, vomiting, headache, respiratory difficulties; arrhythmias; rare: serious infections (skin and soft tissue) at injection site, stress cardiomyopathy.
Epipen Clinical Trials
See Literature
Epipen Note
Not Applicable
Epipen Patient Counseling
See Literature
