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Adrenalin Generic Name & Formulations
Legal Class
Rx
General Description
Epinephrine (as HCl) 1mg/mL; soln for IM, SC, or IV inj; contains sulfites.
Pharmacological Class
Sympathomimetic.
How Supplied
Single-dose vials (1mL)—1, 25; Multi-dose vials (30mL)—1
Manufacturer
Adrenalin Indications
Indications
Emergency treatment of allergic reactions (Type I), including anaphylaxis.
Adrenalin Dosage and Administration
Adults and Children
Do not dilute. Inject into the anterolateral aspect of the thigh. ≥30kg: 0.3–0.5mg SC or IM; max: 0.5mg per inj. <30kg: 0.01mg/kg SC or IM; max: 0.3mg per inj. Both: may repeat every 5–10 mins as necessary; rotate inj sites. Monitor clinically for reaction severity and cardiac effects.
Adrenalin Contraindications
Not Applicable
Adrenalin Boxed Warnings
Not Applicable
Adrenalin Warnings/Precautions
Warnings/Precautions
Avoid injecting into the buttocks, digits, hands, feet, deltoid. Coronary artery disease. Cardiomyopathy. Hypertension. Hyperthyroidism. Parkinson's disease. Diabetes. Monitor BP frequently. IV: avoid extravasation. Elderly. Pregnancy. Labor & delivery: avoid during 2nd stage of labor or when maternal BP >130/80mmHg. Nursing mothers.
Adrenalin Pharmacokinetics
See Literature
Adrenalin Interactions
Interactions
Antagonized by α-blockers (eg, phentolamine), vasodilators (eg, nitrates), diuretics, antihypertensives, ergots, phenothiazine antipsychotics. Potentiated by other sympathomimetics, β-blockers (eg, propranolol), tricyclic antidepressants, MAOIs, COMT inhibitors (eg, entacapone), clonidine, doxapram, oxytocin. Increased arrhythmias with concomitant β-blockers, anesthetics (eg,halothane), antihistamines, thyroid hormones, diuretics, cardiac glycosides (eg, digitalis), quinidine. Hypokalemia with potassium-depleting diuretics, corticosteroids, theophylline.
Adrenalin Adverse Reactions
Adverse Reactions
Anxiety, apprehensiveness, restlessness, tremor, weakness, dizziness, sweating, palpitations, pallor, nausea, vomiting, headache, respiratory difficulties; pulmonary edema, renal impairment, arrhythmias; rare: serious infections at the inj site.
Adrenalin Clinical Trials
See Literature
Adrenalin Note
Not Applicable
Adrenalin Patient Counseling
See Literature
Adrenalin Generic Name & Formulations
Legal Class
Rx
General Description
Epinephrine (as HCl) 1mg/mL; soln for IM, SC, or IV inj; contains sulfites.
Pharmacological Class
Sympathomimetic.
How Supplied
Single-dose vials (1mL)—1, 25; Multi-dose vials (30mL)—1
Manufacturer
Adrenalin Indications
Indications
To increase mean arterial blood pressure in adults with hypotension associated with septic shock.
Adrenalin Dosage and Administration
Adult
Dilute 1mg in 1000mL solution (1mcg/mL); see full labeling. Give by IV infusion after dilution. Initiate at 0.05–2mcg/kg/min; may titrate in increments of 0.05–0.2mcg/kg/min every 10–15mins to desired mean arterial pressure. After hemodynamic stabilization, may withdraw gradually.
Children
Not established.
Adrenalin Contraindications
Not Applicable
Adrenalin Boxed Warnings
Not Applicable
Adrenalin Warnings/Precautions
Warnings/Precautions
Avoid injecting into the buttocks, digits, hands, feet, deltoid. Coronary artery disease. Cardiomyopathy. Hypertension. Hyperthyroidism. Parkinson's disease. Diabetes. Monitor BP frequently. IV: avoid extravasation. Elderly. Pregnancy. Labor & delivery: avoid during 2nd stage of labor or when maternal BP >130/80mmHg. Nursing mothers.
Adrenalin Pharmacokinetics
See Literature
Adrenalin Interactions
Interactions
Antagonized by α-blockers (eg, phentolamine), vasodilators (eg, nitrates), diuretics, antihypertensives, ergots, phenothiazine antipsychotics. Potentiated by other sympathomimetics, β-blockers (eg, propranolol), tricyclic antidepressants, MAOIs, COMT inhibitors (eg, entacapone), clonidine, doxapram, oxytocin. Increased arrhythmias with concomitant β-blockers, anesthetics (eg,halothane), antihistamines, thyroid hormones, diuretics, cardiac glycosides (eg, digitalis), quinidine. Hypokalemia with potassium-depleting diuretics, corticosteroids, theophylline.
Adrenalin Adverse Reactions
Adverse Reactions
Anxiety, apprehensiveness, restlessness, tremor, weakness, dizziness, sweating, palpitations, pallor, nausea, vomiting, headache, respiratory difficulties; pulmonary edema, renal impairment, arrhythmias; rare: serious infections at the inj site.
Adrenalin Clinical Trials
See Literature
Adrenalin Note
Not Applicable
Adrenalin Patient Counseling
See Literature
